In Episode 1 of "Doctor Cha," Cha Jeong-suk, a former doctor turned full-time housewife, reflects on her longing for her medical career. While contemplating her choices, she witnesses a man collapsing on a bus and reluctantly decides to help. With the assistance of Doctor Roy Kim, they save the man's life. Jeong-suk's husband, Chief Surgeon Seo In-ho, is revealed to be having an affair with another woman. Jeong-suk's mother-in-law, obsessed with a healthy lifestyle, belittles career women. Jeong-suk's health deteriorates, and she is diagnosed with acute hepatitis. In-ho neglects her, and she is admitted to the hospital with her mother as her guardian. Jeong-suk's path crosses with Doctor Roy again, who helps her during her treatment. Jeong-suk's condition worsens, and she needs a liver transplant. In-ho's mother refuses to allow him to be a donor, causing tension. Eventually, In-ho agrees, but his mother interferes, tearing up the consent forms. Jeong-suk undergoes the transplant and confronts In-ho after awakening.
Sa Episode 1 ng "Doctor Cha," si Cha Jeong-suk, isang dating doktor na naging full-time housewife, ay sumasalamin sa kanyang pananabik para sa kanyang medikal na karera. Habang pinag-iisipan ang kanyang mga pagpipilian, nasaksihan niya ang isang lalaking bumagsak sa isang bus at atubiling nagpasiya na tumulong. Sa tulong ni Doctor Roy Kim, nailigtas nila ang buhay ng lalaki. Ang asawa ni Jeong-suk, ang Chief Surgeon na si Seo In-ho, ay ipinahayag na nakikipag-relasyon sa ibang babae. Ang biyenan ni Jeong-suk, na nahuhumaling sa isang malusog na pamumuhay, ay minamaliit ang mga babaeng may karera. Ang kalusugan ni Jeong-suk ay lumala, at siya ay nasuri na may talamak na hepatitis. Pinabayaan siya ni In-ho, at ipinasok siya sa ospital kasama ang kanyang ina bilang tagapag-alaga. Nagkrus muli ang landas ni Jeong-suk kay Doctor Roy, na tumutulong sa kanya sa panahon ng kanyang paggamot. Lumalala ang kondisyon ni Jeong-suk, at kailangan niya ng liver transplant. Tumanggi ang ina ni In-ho na maging donor, na nagdulot ng tensyon. Sa kalaunan, pumayag si In-ho, ngunit nakialam ang kanyang ina, pinunit ang mga form ng pahintulot. Sumailalim si Jeong-suk sa transplant at hinarap si In-ho pagkagising.
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